Fig. 4: 89Zr-mA1 as a probe for monitoring inflammation in the B16F10 melanoma mouse model. | npj Imaging

Fig. 4: 89Zr-mA1 as a probe for monitoring inflammation in the B16F10 melanoma mouse model.

From: Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer

Fig. 4: 89Zr-mA1 as a probe for monitoring inflammation in the B16F10 melanoma mouse model.The alternative text for this image may have been generated using AI.

A Schematic overview of the experimental design. B Representative PET/CT images of tumor-bearing animals scanned 24 h after tracer injection. Arrow indicates the tumor, delineated in red. C PET-based quantification of 89Zr-mA1 tumor uptake 24 h post tracer injection (n = 10). D 89Zr-mA1 uptake in the tumor measured by ex vivo gamma counting, (n = 4–10). E Mice were injected with natZr-mA1 14 days after tumor inoculation. 24 h after injection, mice were euthanized and CyTOF performed on the tumor (n = 3). t-SNE plot of viable leukocytes in the tumor, color-coded for natZr-mA1 uptake and the expression of various myeloid cell markers. F Quantification of cellular subsets in the tumor. G Percentage of natZr-positive cells within each subset. H Relative abundance of natZr-positive cell subsets in the tumor (right). **P < 0.01, ***P < 0.005.

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