Table 1 Relaxivities of monomeric and tetrameric probes bearing CBP1 and CBP2 peptide moieties, in PBS and 0.6 mM human serum albumin (HAS) at 20 MHz and 37 °C

From: Non-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis

Compound$

r1 mM (mM−1 s−1)

PBS

HSA 0.6 mM

Gadovist45

3.7

6.1*

Gd-DOTAMA-CBP1

7.4 ± 0.1

8.3 ± 0.2

Gd-DOTAMA-CBP2

8.8 ± 0.2

10.4 ± 0.2

[Gd-DOTAMA]4-CBP1

  

• per molecule

27.2 ± 0.4

28.6 ± 0.4

• per Gd(III)

6.8 ± 0.1

7.2 ± 0.1

  1. $ All Gd concentrations were confirmed by inductively coupled plasma (ICP) and/or bulk magnetic susceptibility (BMS)90; * in non-sterile bovine plasma (corresponding to an albumin concentration of 0.64 to 0.82 mmol/L)19,21,45,50.
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