Fig. 1: Determining the optimal concentration of the β-gal responsive Gd-chelate for MRI detection of β-gal Gd-chelate ‘activation’. | npj Imaging

Fig. 1: Determining the optimal concentration of the β-gal responsive Gd-chelate for MRI detection of β-gal Gd-chelate ‘activation’.

From: MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate

Fig. 1: Determining the optimal concentration of the β-gal responsive Gd-chelate for MRI detection of β-gal Gd-chelate ‘activation’.The alternative text for this image may have been generated using AI.

A Representative axial T1-weighted MR images of test tubes with increasing concentrations of the β-gal responsive Gd-chelate, with and without the addition of 10U β-gal enzyme at pH 6.0. B Mean T1 relaxation times of increasing concentrations of the β-gal responsive Gd-chelate with and without the addition of 10U β-gal enzyme. C Corresponding T1 maps are color-coded to depict T1-shortening visually. D Mean R1 relaxation rates of increasing concentrations of the β-gal responsive Gd-chelate with and without the addition of 10U β-gal enzyme.

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