Fig. 2: Clinical, virologic, and pathological analyses support a typical time course of Ebola virus infection in the domestic ferret model. | npj Imaging

Fig. 2: Clinical, virologic, and pathological analyses support a typical time course of Ebola virus infection in the domestic ferret model.

From: Reactive oxygen species-related oxidative changes are associated with splenic lymphocyte depletion in Ebola virus infection

Fig. 2: Clinical, virologic, and pathological analyses support a typical time course of Ebola virus infection in the domestic ferret model.

a Cageside monitoring of ferrets: clinical scores (left), weight (middle), and % weight change (right) over the course of the study (Supplementary Table 3). b Virologic assays: real-time reverse transcription polymerase chain reaction (RT-qPCR; left) analysis of spleen, plasma, and liver tissues. Plaque assay data (right) from analysis of spleen and liver tissues (Supplementary Table 4). c From left to right, representative image for gross pathology, hematoxylin and eosin (H&E) histopathology, Ebola virus (EBOV) matrix protein (VP40) immunohistochemistry (IHC) in ferret spleens (top), livers (middle), and kidneys (bottom) at 3 d post-exposure (dpe) scheduled necropsy (top) and day terminal (dt, bottom).

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