Fig. 5: Ex vivo analysis comparing lipid peroxidation and CJ215 uptake in mouse kidney. | npj Imaging

Fig. 5: Ex vivo analysis comparing lipid peroxidation and CJ215 uptake in mouse kidney.

From: Phosphatidylserine exposure and plasma membrane perforation as ferroptotic signatures for in vivo imaging

Fig. 5

a Quantification of lipid peroxidation levels in the live cell populations of kidney cells from mice groups serving as Control, IKE treated, IKE+Liproxstatin treated. b Quantification of CJ215 positive cells from the live cell populations of the same group. c Bodipy C11 signal indicating lipid peroxidation and their histogram distribution where we selected low and high lipid peroxidation populations marking the 10% of cells on either end. d Comparison of mean CJ215 fluorescence signal in low and high lipid peroxidation populations in each mouse group, indicating an increased CJ215 uptake in cells with higher lipid peroxidation. N = 3 mice per group.

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