Fig. 9: Biodistribution and clearance pathways of JAM317 in mice.
From: Low molecular weight 4,4’-quinocyanines for in vivo NIR-II fluorescence imaging
A NIR-II fluorescence image of a mouse injected tail vein i.v. with JAM317 (40 nmol) in eggPC liposomes, with regions of interest (ROIs) drawn around key organs, including the heart, liver, lungs, bladder, lymph nodes, and intestines. B Fluorescence intensity versus time for the ROIs, showing the initial distribution of JAM317 through the heart, followed by systemic perfusion and subsequent accumulation in the liver over time. The periodic beat pattern in the time course represents the breathing rate of the animal C NIR-II fluorescence image of the mouse 24 h post-injection, illustrating dye localization primarily in the intestines. D Ex vivo fluorescence images of harvested organs 2 h post-injection, confirming high fluorescence in the liver and moderate fluorescence in the lungs, spleen, and intestines, with minimal fluorescence in the bladder, indicating hepatic metabolism as the dominant clearance pathway.
