Fig. 3: 19F content and spatial distribution in tumor-bearing mice.
From: Linking tumor viability and immune infiltration with dual-nucleus MRI in preclinical models
A Experimental timeline for single timepoint tumor imaging after repeated PFC injection. B Quantification of 19F spins in spleens, inguinal lymph nodes, and mOatp1a1-expressing tumors at endpoint. C Correlation analysis between tumor volume and total intratumoral 19F content. D Frequency of 19F signal observed in distinct tumor regions (viable, periphery, necrotic core, and transition zone). E Representative 1H/19F image pairs illustrating spatial PFC signal distribution across tumors with increasing 19F content (scale bar = 4 mm). F, G Confocal images showing co-localization of VS-DM-Red with F4/80⁺ macrophages in viable and necrotic tumor regions (scale bar = 20 μm) PFC co-localized with F4/80+ cells (yellow arrows), F4/80+ cells lacking PFC (green arrows), PFC+ in F4/80- cells (white arrows). * p < 0.05, ** p < 0.01.
