Fig. 3: Regulation of RNA function by metabolites.
From: Regulation of gene expression through protein-metabolite interactions
Metabolites can affect translation by binding to riboswitches. A Binding of the metabolite thiamine pyrophosphate (TPP) to the thiM riboswitch induces a conformational change masking the Shine-Dalgarno sequence (SD) inhibiting ribosome binding and translation initiation. B RNA molecules can inhibit metabolic enzymes such as the glycolytic enzyme ENO1 which is relevant for mESC differentiation. C Metabolites can allosterically regulate RNA-binding proteins. Unsaturated lipids allosterically inhibit RNA binding of MSI1 which leads to the translational down-regulation of the lipid biosynthesis enzyme SCD and to changes in lipid metabolism. mESC mouse embryonic stem cells, MSI1 Musashi 1, SCD steaoryl-Coa desaturase 1.
