Fig. 3: Mediation analysis of MAFLD-related metabolites for the association between MAFLD with cognitive function trajectories.

The outcome in the figure indicates a large decrease pattern of MMSE. A Contribution of LysoPC; B Contribution of LysoPE; C Contribution of Valine. Adjusted for age, sex, body mass index, education, physical activity, smoking, and drinking, hypertension, dyslipidemia, estimated glomerular filtration rate, and alanine transaminase. MAFLD metabolic dysfunction-associated fatty liver disease *P < 0.05; **P < 0.01; ***P < 0.001