Table 1 Baseline characteristics

From: Longitudinal association of metabolic dysfunction-associated fatty liver disease, serum metabolites, with cognitive function trajectories

Characteristics

Overall (n = 845)

Non-MAFLD (n = 568)

MAFLD (n = 277)

P value

Age, years

49.10 (40.56–59.62)

45.21 (34.6–57.35)

57.84 (48.02–62.31)

<0.0001

Men, n (%)

300 (35.50)

166 (29.23)

134 (48.38)

<0.0001

Education, n (%)

   

<0.0001

Illiteracy/primary school

45 (5.33)

24 (4.23)

21 (7.58)

 

Junior high school

430 (50.89)

255 (44.89)

175 (63.18)

 

College or higher

370 (43.79)

289 (50.88)

81 (29.24)

 

Active physical activity, n (%)

477 (56.45)

300 (52.82)

177 (63.90)

0.0095

Current smoking, n (%)

159 (18.82)

85 (14.96)

74 (26.71)

<0.0001

Current drinking, n (%)

132 (15.62)

79 (13.91)

53 (19.13)

0.0495

Hypertension, n (%)

104 (12.31)

34 (5.99)

70 (25.27)

<0.0001

Diabetes, n (%)

36 (4.26)

10 (1.76)

26 (9.39)

<0.0001

Dyslipidemia, n (%)

54 (6.39)

12 (2.11)

42 (15.16)

<0.0001

Antihypertensive agents, n (%)

88 (10.41)

26 (4.58)

62 (22.38)

<0.0001

Antidiabetic agents, n (%)

31 (3.67)

10 (1.76)

21 (7.58)

<0.0001

Lipid-lowering agents, n (%)

13 (1.54)

4 (0.70)

9 (3.25)

0.0048

Body mass index, kg/m2

23.40 (21.40–25.70)

22.23 (20.4–23.76)

26.30 (24.44–28.60)

<0.0001

Systolic blood pressure, mmHg

120.00 (111.00–130.00)

116.00 (107.00–125.00)

129.00 (119.50–143.00)

<0.0001

Diastolic blood pressure, mmHg

76.00 (69.00–84.00)

73.00 (68.00–81.00)

82.00 (75.00–89.00)

<0.0001

Fasting blood glucose, mmol/L

5.00 (4.70–5.40)

4.90 (4.70–5.20)

5.30 (4.90–5.90)

<0.0001

Total cholesterol, mmol/L

4.39 ± 0.81

4.26 ± 0.72

4.66 ± 0.91

<0.0001

Triglyceride, mmol/L

1.00 (0.73–1.37)

0.90 (0.68–1.16)

1.36 (0.97–1.77)

<0.0001

LDL cholesterol, mmol/L

2.35 (2.01–2.78)

2.26 (1.95–2.64)

2.62 (2.23–3.09)

<0.0001

HDL cholesterol, mmol/L

1.23 (1.08–1.44)

1.31 (1.14–1.49)

1.12 (0.99–1.27)

<0.0001

Triglyceride-glucose index

8.29 (7.97–8.66)

8.18 (7.87–8.46)

8.69 (8.31–9.08)

<0.0001

eGFR, ml/min/1.73 m2

92.92 ± 15.27

94.92 ± 15.71

88.82 ± 13.44

<0.0001

Serum uric acid, μmol/L

261.75 (214.90–317.00)

243.15 (201.60–293.60)

304.20 (251.85–359.30)

<0.0001

Alanine transaminase, U/L

15.90 (11.90–22.60)

14.10 (11.10–19.40)

20.00 (15.30–27.00)

<0.0001

Aspartate aminotransferase, U/L

20.00 (18.00–24.00)

20.00 (17.00–23.00)

21.00 (18.00–26.00)

<0.0001

γ-Glutamyl Transferase, U/L

16.30 (12.00–23.00)

14.35 (11.10–19.10)

21.50 (16.10–32.80)

<0.0001

  1. eGFR estimated glomerular filtration rate.