Fig. 3: Local ECM-associated disease drives systemic dysfunction, but new therapies can revert the course.
From: ECM formation and degradation during fibrosis, repair, and regeneration
Schematic highlighting the state-of-the-art of organ regeneration technology (left), and the “Organ death races” that are triggered by local, ECM-associated disease, emphasizing liver and adipose tissue as sources of syndrome-like and ultimately lethal events (right).
