Fig. 6: Differentially expressed genes related to increased fat calorie diet, maternal postpartum running, and the combination of the two.

A Sed^21% vs. Sed^13% DEGs enriched in lipid metabolic processes mapped to FA transport and beta oxidation metabolic pathways. DEGs in Run^21% vs. Run^13% are in parentheses. Abcd3 (ATP binding cassette subfamily D member 3), Acaa1b (3- ketoacyl-CoA thiolase B), Acox1 and Acox2 (acyl-coenzyme A oxidase), Cat (carnitine O-acetyltransferase), Crot (carnitine O-octanoyltransferase), Eci2 (enoyl-CoA delta isomerase 2), Decr1 (2,4-dienoyl-CoA reductase 1), Hacl1 (2-hydroxyacyl-CoA lyase 1), Hadh (3-hydroxyacyl-CoA dehydrogenase), Slc27a2 (solute carrier for long-chain FAs. FA: fatty acid; MFA, medium-chain FA; LCFA, long-chain FA; VLCA, very-long-chain FA. B Run^13% vs. Sed^13% DEGs mapped to lipid/FA metabolic processes. Hacd3 (3-Hydroxyacyl-CoA dehydratase 3), Cpt1a (carnitine palmitoyltransferase 1A), Acsf2 (acyl-CoA synthetase family member 2). C Run^21% vs. Sed^13% DEGs mapped to lipid/FA metabolic processes. Fasn (FA synthase), Dgat2 (diacylglycerol acyltransferase). D Overlap between diet, maternal environment, and diet + maternal environment-induced DEGs. E–G Overlap between DEGs related to pairs of conditions in (D) is split into up- and downregulated genes.