Fig. 7: Differential gene expression in Kupffer cells as a function of the diet, Run maternal environment, and the combination of the two.

A 21% diet-induced change in gene expression in Sed males. Up- (+) and downregulated (–) genes are indicated by light blue dots in a volcano plot. B Enrichment of Sed^21% vs. Sed^13% DEGs in GO biological processes. Upregulated genes are enriched in immunity-related biological processes. C–F Same as (A, B) but for Run^13% vs. Sed^13% and Run^21% vs. Sed^13% DEGs, respectively.