Fig. 3: Il6 variant CC genotype increases systemic IL6 levels but does not exacerbate adipose tissue inflammation in HFD mice of either sex.
From: An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice
A IL6 concentration (pg/ml) in the plasma of male and female HFD mice. B Total adipose myeloid cell population (% of CD45+ parent cell population) in subcutaneous (sub) and gonadal fat pads of male and female HFD mice. C Total macrophage cell population (% of myeloid cell lineage) in subcutaneous (sub) and gonadal fat pads of male and female HFD mice. D M1 (pro-inflammatory) to M2 (anti-inflammatory) ratio of macrophages per gram of individual fat pad weight in subcutaneous (sub) and gonadal fat pads of male and female HFD mice. Data are presented as individual values, mean ± SEM. n = 8–10 per group. Data were analyzed by Mann–Whitney U-test (A) and Student’s T-test (B–D). Significance was determined at *p < 0.05, **p < 0.01 and ***p < 0.001.
