Table 3 The Il6 variant CC genotype has differential effects on cardiac and cardiomyocyte size in HFD-fed male and female mice
From: An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice
HFD Male | HFD Female | |||
|---|---|---|---|---|
GG control | CC variant | GG control | CC variant | |
Left ventricular mass (mg) | 112.9 ± 6.6 | 119.4 ± 8.7 | 104.5 ± 5.6 | 92.5 ± 4.0 |
CM area (µm2) | 1402 ± 97.1 | 1061 ± 86.0* | 1104 ± 83.3 | 1358 ± 52.4** |
CM length (µm) | 82.6 ± 3.1 | 69.9 ± 3.2** | 72.3 ± 4.0 | 82.6 ± 1.9* |
CM width (µm) | 18.1 ± 0.7 | 15.7 ± 0.9 | 16.2 ± 0.5 | 18.3 ± 0.4** |
Estimated myocyte number | 12,905,217 | 18,016,092 | 14,043,478 | 10,392,174 |
