Table 1 Mechanistic insight into HMGB1 in ischaemic heart disease (detrimental effects)
From: Scoping review of preclinical and clinical studies on the role of HMGB1 in heart disease
Authors (Year) | Study population (Model) | Agonist HMGB1 (Supplier) | Antagonist of HMGB1 | Receptors and pathways |
|---|---|---|---|---|
Andrassy et al. (2008)32 | C57Bl/6WT & RAGE−/− mice (IR) | rHMGB1 (non-specified) | Box A | RAGE; JNK/ERK/ NF-κB |
Cai et al. (2017)65 | SD rats (IR) | – | Glycyrrhizin | ERK/p38/MAPK/JNK |
Chen et al. (2019)63 | SD rats (CME) | – | siRNA | – |
Di Maggio et al. (2017)21 | Human cardiac fibroblasts (Hypoxia); C57Bl/6mice (PL) | 3SHMGB1 (in-house production) | – | CXCR4 |
Lusha et al. (2017)60 | SD rats (IR) | – | siRNA | – |
Han et al. (2024)136 | H9c2 cells (H/R); C57Bl/6mice (IR) | – | Glycyrrhizin | – |
Hu et al. (2018)35 | NRCM (IR) | rHMGB1 (not-specified) | Anti-HMGB1 | IL-17A |
Hu et al. (2022)61 | RAW264.7 macrophages (Hypoxia) | HMGB1 overexpression by transfection | siRNA | Foxp1 |
Mersmann et al. (2013)33 | C57Bl/6 & TLR-2−/− mice (IR) | rHMGB1 (eBioscience) | Box A | TLR-2 |
Ouyang et al. (2016)62 | H9c2 cells (H/R); SD rats (IR) | HMGB1 overexpression by transfection | shRNA | Discoidin Domain Receptor 1 (DDR1) |
Ren et al. (2020)66 | C57Bl/6WT & TLR-4−/− mice (ISO) | rHMGB1 (Sigma-Aldrich) | – | TLR-4 |
Tian et al. (2019)41 | C57Bl/6WT & RAGE−/− & TLR-9−/− mice (IR) | rHMGB1 (Thermo Fisher) | Immunoprecipitation | RAGE/TLR-9 |
Volz et al. (2010)29 | C57Bl/6WT & RAGE−/− mice (IR) | rHMBG1 (not-specified) | Box A | RAGE |
Xia et al. (2018)36 | SD rats (IR) | – | Anti-HMGB1 | – |
Xu et al. (2011)34 | NMCM (A/R); C57Bl/6 & TLR-4−/− mice (IR) | rHMGB1 (Abcam) | Box-A | TLR-4/JNK/P65 |
Xue et al. (2019)37 | SD rats (IR) | – | Anti-HMGB1 | TLR-4/MyD88/NF-κB |
Yuan et al. (2021)59 | SD rats (CME) | – | Glycyrrhizin | TLR-4/NF-κB |
Zhai et al. (2012)40 | SD rats (IR) | rHMGB1 (not-specified) | Glycyrrhizin | pJNK/Bax |
Zhao et al. (2023)127 | Human microvascular endothelial cells (STEMI patients) | rHMBG1 (HMGBiotech)# | Box A | TLR-4 |
Zhu et al. (2024)64 | H9c2 cells (H/R); SD rats (IR) | – | Glycyrrhizin | TLR-4/GPX4 |
