Table 2 Mechanistic insight into HMGB1 in ischaemic heart disease (beneficial effects)
From: Scoping review of preclinical and clinical studies on the role of HMGB1 in heart disease
Authors (Year) | Study population (Model) | Agonist HMGB1 (Supplier) | Antagonist of HMGB1 | Receptors and pathways |
|---|---|---|---|---|
Abarbanell et al. (2011)67 | SD rats (Langendorff) | rHMGB1 (Sigma-Aldrich) | – | – |
Bauzá et al. (2019)47 | Corriedale sheep (PL) | rHMGB1 (HMGBiotech)# | – | – |
Di Maggio et al. (2017)21 | Human cardiac fibroblasts (Hypoxia); C57Bl/6mice (PL) | frHMGB1 (In-house production) | – | CXCL12/CXCR4 |
Foglio et al. (2017)73 | C57Bl/6mice (PL) | rHMGB1 (In-house production) | – | TLR-9/RAGE; AMPK/Akt/mTOR |
He et al. (2013)46 | SD rats (PL) | rHMGB1 (not-specified) | – | – |
Kitahara et al. (2008)31 | WT&HMGB1-TG mice (PL) | Cardiomyocyte-specific HMGB1 overexpression (α-MHC promoter) | – | – |
Kohno et al. (2009)30 | Human (STEMI); Wistar rats (PL) | – | Anti-HMGB1 | – |
Limana et al. (2005)45 | C57Bl/6mice (PL) | rHMGB1 (In-house production) | Box A | c-kit+ cardiac stem cells |
Limana et al. (2010)130 | Human (MI); C57Bl/6mice (PL) | – | – | c-kit+ cardiac stem cells |
Limana et al. (2013)74 | C57Bl/6mice (PL) | rHMGB1 (In-house production) | – | Notch |
Liu et al. (2019)72 | Human (DCM); C57Bl/6WT&TLR-9-/- mice (PL) | rHMBG1 (R&D) | – | TLR-9 |
Liu et al. (2024)137 | Cardiac endothelial cells (Hypoxia) | – | siRNA | YAP1 |
Lozano et al. (2022)138 | hiPSCs, CMs, HUVECs, hCFs (Hypoxia) | HMGB1 (Stem-cell derived EVs) | – | – |
Nakamura et al. (2015)48 | C57Bl/6WT & HMGB1-TG mice (PL) | Cardiomyocyte-specific HMGB1 overexpression (α-MHC promoter) | – | – |
Oozawa et al. (2008)44 | Wistar Rats (IR) | – | anti-HMGB1 | Norepinephrine |
Rossini et al. (2008)139 | hCFs and mouse CSCs (Hypoxia) | HMGB1(HMGBiotech)# | – | RAGE |
Yao et al. (2016)71 | Wistar rats (IR) | rHMGB1 (R&D) | – | HIF-1α/PI3K/AKT |
Zhou et al. (2012)68 | SD rats (PL) | rHMGB1 (not-specified) | – | β-catenin/Dishevelled-1 |
Zhou et al. (2017)70 | Wistar Rats (IR) | rHMGB1 (Sino Biological Inc.) | – | HIF-1α/p38 MAPK |
Zhou et al. (2020)69 | Wistar rats (IR) | rHMGB1 (not-specified) | – | PI3K/Akt |
