Fig. 4: FIDA analysis of the binding affinities of different complexes between NabFab, the grafted nanobodies NBg1 and NBg2 and αSOs. | npj Biosensing

Fig. 4: FIDA analysis of the binding affinities of different complexes between NabFab, the grafted nanobodies NBg1 and NBg2 and αSOs.

From: Nanobodies raised against the cytotoxic α-synuclein oligomer are oligomer-specific and promote its cellular uptake

Fig. 4: FIDA analysis of the binding affinities of different complexes between NabFab, the grafted nanobodies NBg1 and NBg2 and αSOs.The alt text for this image may have been generated using AI.

a NabFab binding to NBg1. b NabFab binding to NBg2. c NBg1 binding to αSOs. d NBg2 binding to αSOs. e NBg1:NabFab binding to αSOs. f NBg2:NabFab binding to αSOs. g SPR data of binding of NBg1:NabFab to αSOs (immobilized as in Fig. 2b, c). In all cases, data are fitted with a 1:1 binding curve and the dissociation constant KD is provided. Errors based on triplicates.

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