Fig. 2: Differential expression of GluR2 + EV miRNAs, GLAST + EV miRNAs, and plasma proteins in the LBD (n = 30 patients) versus AD (n = 31 patients) comparison. | npj Biosensing

Fig. 2: Differential expression of GluR2 + EV miRNAs, GLAST + EV miRNAs, and plasma proteins in the LBD (n = 30 patients) versus AD (n = 31 patients) comparison.

From: Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer’s disease

Fig. 2: Differential expression of GluR2 + EV miRNAs, GLAST + EV miRNAs, and plasma proteins in the LBD (n = 30 patients) versus AD (n = 31 patients) comparison.The alternative text for this image may have been generated using AI.

A Heatmap of z-score of log2(expression) for biomarkers with Benjamini-Hochberg FDR-corrected P value < 0.1. Subjects (columns) are hierarchically clustered within cohort and biomarkers within each compartment (rows) are sorted by descending fold-change. B Volcano plot demonstrating differential expression of GluR2+ EV miRNAs, GLAST + EV miRNAs, and plasma proteins. C Venn diagram showing overlap in FDR P value significant miRNAs (P value < 0.1) between GluR2+ EVs and GLAST+ EVs. D Top 30 biomarkers in all compartments ranked by descending area under the curve (AUC). Error bars represent standard error from bootstrapping 10x.

Back to article page