Fig. 1: Influencers of clinical course in end-stage liver disease.

The multifaceted care approach aims to equally address a organ failure and the complications of portal hypertension; b relevant comorbidities affecting candidacy and posttransplant health; c environmental and social determinants of health; and d physical fitness or physiological reserve. Such comprehensive care is expected to improve overall health and translate into better quality of life and survival both pre- and posttransplant.