Table 1 Characteristics of patients included in the study

From: Stiffness-induced modulation of ERG transcription factor in chronic liver disease

Variable

C (n = 9)

1 DC (n = 10)

>1 DC (n = 10)

Total (n = 29)

Age (years)

56.56 ± 7.51

51.9 ± 15.62

52.7 ± 7.243

53.62 ± 10.75

Sex: M/F (%)

33/67

40/60

50/50

41/59

Etiology: HCV/HBV/ARLD/MASH/others$ (%)

56/11/0/22/11

40/10/0/0/50

10/10/50/10/20

34/10/17/10/28

CSPH: N/Y (%)

22/78

10/90

0/100

10/90

HVPG (mmHg)

14.5 ± 4.9

17.8 ± 6.5

20.3 ± 4.7(**)

17.6 ± 5.8

HCC: N/Y (%)

100/0

100/0

100/0

100/0

Liver stiffness by VCTE (kPa)

26.92 ± 12.83

37.57 ± 20.31

53.55 ± 20.18(**)

35.89 ± 19.13

Ascites: N/Y (%)

100/0

30/70

0/100

41/59

Hepatic encephalopathy: N/Y (%)

100/0

90/10

40/60

76/24

Esophageal variceal hemorrhage: N/Y (%)

100/0

80/20

80/20

86/14

Other decompensations: N/Y (%)

100/0

100/0

60/40

86/14

AST (U/L)

93 ± 80

80 ± 40

154 ± 112

110 ± 87

ALT (U/L)

78 ± 63

45 ± 22

58 ± 35

60 ± 43

GGT (U/L)

120 ± 140

53 ± 31

316 ± 272

160 ± 202

ALP (U/L)

439 ± 191

353 ± 155

408 ± 230

397 ± 189

INR

1.42 ± 0.48

1.58 ± 0.26

1.70 ± 0.51(*)

1.57 ± 0.43

Bilirubin (mg/dL)

2.22 ± 3.26

2.97 ± 1.46(**)

11.26 ± 12.03(**)

5.72 ± 8.33

PLT (x103/uL)

129.60 ± 90.94

85.80 ± 32.57

146.80 ± 113

120.40 ± 86.66

Albumin (g/dL)

3.94 ± 1.31

3.12 ± 0.40(**)

2.99 ± 0.43(**)

3.29 ± 0.83

Na (mmol/L)

138.3 ± 4.41

139.8 ± 3.01

135.9 ± 6.33

138.0 ± 4.96

MELD

13 ± 11

15 ± 3

20 ± 8(*)

16 ± 8

Child-Pugh class: A/B/C/NA (%)

67/11/0/22

0/60/40/0

0/20/80/0

21/31/41/7

FIB4 score

8.76 ± 9.28

8 ± 4.52

11.65 ± 13.19

9.49 ± 9.47

Relative ERG area (a.u.)

1.00 ± 0.27

1.09 ± 0.41

0.99 ± 0.17

1.03 ± 0.29

  1. $Other etiologies are represented by autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis. (**) statistically significantly different values compared to compensated patients, p < 0.05 (*) statistically significantly different values compared to compensated patients, p < 0.1.
  2. Categorical variables are expressed in % and continuous variables in mean ± SD. Sample distributions were assessed for normality (Kolmogorov-Smirnov test). Normally distributed data were compared with unpaired Student t test or with Ordinary One-way ANOVA test. M male, F female, HCV hepatitis C virus, HBV hepatitis B virus, ARLD alcoholic liver disease, MASH non-alcoholic steatohepatitis, CSPH clinically significant portal hypertension, HVPG hepatic venous pressure gradient, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyl transferase, ALP alkaline phosphatase, INR international normalized ration, PLT platelets, MELD model for end stage liver disease, NA missing data, VCTE vibration-controlled transient elastography.
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