Table 3 Secondary patient reported outcomes across different age groups in IBS

PHQ-12 Non-GI somatic symptoms

(n = 1161)

(n = 409)

7.7 ± 3.8

(n = 475)

7.5 ± 4.1^b

(n = 277)

6.6 ± 3.7^c

<0.0001

HADS; Psychological distress (n = 1508)

(n = 502)

(n = 626)

(n = 380)

 Anxiety

7.9 ± 4.4^a

7.1 ± 4.4

6.2 ± 4.2^c

<0.0001

 Depression

4.7 ± 3.3

5.0 ± 3.7^b

4.7 ± 3.6

NS

VSI; GI-specific anxiety (n = 1223)

(n = 438)

44 ± 16^a

(n = 521)

40 ± 16^b

(n = 264)

35 ± 16^c

<0.0001

IBS quality of life (%) (n = 986)

(n = 330)

(n = 421)

(n = 235)

Emotional

49 ± 21

52 ± 23^b

58 ± 21^c

<0.0001

Mental

70 ± 22

73 ± 21^b

78 ± 18^c

<0.0001

Sleep

76 ± 22

74 ± 23^b

67 ± 24^c

<0.0001

Energy

57 ± 26

59 ± 28

58 ± 26

NS

Physical function

74 ± 20

72 ± 23

72 ± 25

NS

Food

60 ± 20^a

66 ± 19

66 ± 19^c

<0.0001

Social role

61 ± 22^a

66 ± 24

64 ± 22

<0.05

Physical role

57 ± 30

61 ± 31

63 ± 29^c

<0.05

Sexual relations

63 ± 26

64 ± 27

63 ± 29

NS