Fig. 1: Schematic overview of key considerations in the design of cell therapies for treatment of AAA. | npj Biomedical Innovations

Fig. 1: Schematic overview of key considerations in the design of cell therapies for treatment of AAA.

From: Stem cell-based therapies for treatment of abdominal aortic aneurysm: development, application, and future potential

Fig. 1

A Therapeutic cell types, their respective sources, and other considerations. B Cell delivery modalities. C Status of relevant clinical trials. D Common animal models and their general techniques. E The aortic wall layers and relevant cells. VSMCs vascular smooth muscle cells, MSCs mesenchymal stromal cells, ADSCs adipose-derived stem cells, iPSCs induced pluripotent stem cells, ECM extracellular matrix, EMT epithelial-to-mesenchymal transition, AAA abdominal aortic aneurysm, IV intravenous, PPE porcine pancreatic elastase, Ang II angiotensin II, ApoE−/− apolipoprotein E−/− Created in BioRender. Badawy, S. (2025) https://BioRender.com/zf2ju2q.

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