Table 1 VSMC therapies for AAA models

From: Stem cell-based therapies for treatment of abdominal aortic aneurysm: development, application, and future potential

Disease model

Cell type

Delivery Method

Follow-up Time

Output Measurement

Reference

Guinea pig xenograft in Rats

Rat VSMCs

Seeded xenograft

Up to 56 days

VSMC prevented AAA formation, elastin degradation, and inflammatory response

26

Guinea pig xenograft in Rats

Rat SMCs

Injection into graft lumen

Up to 56 days

VMSC prevented further dilation of aneurysm and elastin degradation and inhibits MMP expression

27

Pancreatic porcine elastase infusion in Mice

Human iPSC smooth muscle progenitors or primary human VSMCs

Seeded porous collagen scaffold transplantation

Up to 28 days

VSMCs significantly decreased AAA growth more than iPSCs and had higher immune activity

28

Elastase induced AAA in Rats

VSMC-like progenitors derived from murine skeletal-muscle stem cells

Implantation into AAA lumen

Up to 42 days

VSMC-like progenitors had decreased AAA formation and inhibited MMP expression

29

  1. AAA Abdominal Aortic Aneurysm, MMP Matrix Metalloproteinases, Treg Regulatory T Cells, VSMC Vascular Smooth Muscle Cells
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