Fig. 3: A broad range of physicochemical properties can be imparted through modification to the network hydrophobicity.

A Increasing alkyl chain length significantly broadens the transition with little impact to onset, while (B) increasing steric bulk maintains breadth of transition while offering a substantial decrease in onset. Data represent mean ± SEM (n = 3). C Nanogel effective surface ζ-potential as a function of pH demonstrates that the modifications to the co-polymer composition predominantly affect the network core. For simplicity, shown are the select formulations with varied pHcritical values and volume swelling ratios. Data represent mean ± SEM (n = 3).