Table 1 Summary of nanogel collapsed diameters (measured by DLS), polydispersity index (PDI), critical swelling pH, maximum volume swelling ratio, and breadth of transition from onset to fully swollen given in units of pH(n = 3)
Formulation | Monomer-LogP | pKaa | pH_criticalb | Diameter at pH 7.4 (nm) | PDI | Maximum Volume Swelling Ratio | Breadth of Transition (pH units) |
|---|---|---|---|---|---|---|---|
Original Particle (None) | 1.9 | 7.5 ± 0.12 | 7.36 ± 0.098 | 90.5 | 0.14 | 3.1 | 0.6 |
Methyl Methacrylate | 1.38 | 7.7 ± 0.075 | 7.56 ± 0.115 | 94.3 | 0.1 | 2.37 | 0.7 |
Ethyl Methacrylate | 1.94 | 7.17 ± 0.042 | 7.1 ± 0.076 | 72 | 0.12 | 2.8 | 0.8 |
Butyl Methacrylate | 2.88 | 6.7 ± 0.057 | 6.9 ± 0.055 | 67.5 | 0.09 | 2.7 | 1.2 |
Hexyl Methacrylate | 3.73 | 6.2 ± 0.081 | 6.7 ± 0.063 | 72 | 0.11 | 2.37 | 1.6 |
2-Ethylhexyl Methacrylate | 4.54 | 5.9 ± 0.093 | 6.45 ± 0.101 | 93.1 | 0.12 | 1.52 | 1.6 |
