Table 2 The calculated effective concentration of all nanoparticles tested (shown in mg/mL) for a 50% reduction relative to the positive media control (EC50) for both cell proliferation and viability at all exposure times tested
2 h | 24 h | |||||
|---|---|---|---|---|---|---|
Formulation | pKaa | pH_criticalb | Cell Viabilityc | Cell Proliferationc | Cell Viabilityc | Cell Proliferationc |
Original Particle (None) | 7.5 | 7.36 | 0.71 | >2.0 | 0.11 | 0.69 |
Methyl Methacrylate | 7.7 | 7.56 | 0.91 | >2.0 | 0.1 | 0.71 |
Ethyl Methacrylate | 7.17 | 7.1 | 0.87 | >2.0 | 0.13 | 0.68 |
Isopropyl Methacrylate | 7.05 | 7.1 | 1.33 | >2.0 | 0.11 | 0.97 |
tertButyl Methacrylate | 6.9 | 6.85 | 1.62 | >2.0 | 1.54 | >2.0 |
Phenyl Methacrylate | 6.81 | 6.75 | 1.61 | >2.0 | 1.51 | 1.93 |
Cyclohexyl Methacrylate | 6.56 | 6.6 | >2.0 | >2.0 | >2.0 | >2.0 |
Benzyl Methacrylate | 6.7 | 6.65 | >2.0 | >2.0 | >2.0 | >2.0 |
Butyl Methacrylate | 6.7 | 6.9 | >2.0 | >2.0 | >2.0 | >2.0 |
Hexyl Methacrylate | 6.2 | 6.7 | >2.0 | >2.0 | >2.0 | >2.0 |
2-Ethylhexyl Methacrylate | 5.9 | 6.45 | >2.0 | >2.0 | >2.0 | >2.0 |
