Fig. 6: Typical histopathological image patches identified with PI3K-Akt signaling pathway dysregulation. | npj Biomedical Innovations

Fig. 6: Typical histopathological image patches identified with PI3K-Akt signaling pathway dysregulation.

From: Inferring signaling pathway abnormalities from histopathological images via logic-constrained gene-pathway heterogeneous knowledge graph

Fig. 6: Typical histopathological image patches identified with PI3K-Akt signaling pathway dysregulation.The alternative text for this image may have been generated using AI.

The “After logical knowledge constraints” panel shows histopathological images identified with logical clause constraints applied. The “No logical knowledge constraints” panel shows histopathological images identified without logical clause constraints. The “Clinical Case” panel shows a clinical histopathological image case with mutations in PI3K-Akt pathway–related genes. Images in the “Clinical Case” panel are adapted from the Human Protein Atlas (available at proteinatlas.org) and used under the Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0).

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