Table 2 Comparison of gene groups associated with signaling pathways

Metric	Hamming loss	Mean ACC						Mean AUC
Backbones	Pathway
Backbones	hsa04512	hsa04151	RHSA8948216	hsa04512	hsa04151	RHSA8948216	hsa04512	hsa04151	RHSA8948216
LCG-HGIN	0.1176	0.2429	0.1220	0.8824	0.7571	0.8780	0.8518	0.7214	0.8845
LCG-HGAT	0.0359	0.3235	0.1264	0.9641	0.6765	0.8736	0.9816	0.6851	0.9088
LCG-HSAGE	0.1618	0.2963	0.1983	0.8382	0.7037	0.8017	0.9071	0.6918	0.8952
LCG-HGCN	0.2010	0.2821	0.1852	0.7990	0.7179	0.8148	0.7781	0.6355	0.7646
SAGNN	–	–	–	0.7234	0.6832	0.6598	0.7499	0.7290	0.7183
CNN	–	–	–	0.5094	0.4923	0.5391	0.7705	0.7351	0.7697
AS_Graph	0.8333	0.2789	0.3593	0.1667	0.7211	0.6407	0.5000	0.6956	0.5000
AS_Weight	0.1797	0.2821	0.1438	0.8203	0.7179	0.8562	0.8133	0.7011	0.8740
DAMLN	0.1111	0.2196	0.1852	0.8889	0.8190	0.8148	0.6261	0.4789	0.4080
ADD-GCN	0.1552	0.4545	0.1667	0.4045	0.5455	0.4506	0.5250	0.5536	0.5509
Gene-DML	0.3333	0.2302	0.2407	0.6667	0.7698	0.7593	0.7623	0.7954	0.7942

Bold values indicate the best performance achieved among all compared methods for each metric on the corresponding pathway.

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