Fig. 7: BRI-50460 amyloid-42 oligomer-induced cPLA2α activation and tau phosphorylation in neurons derived from human iPSCs. | npj Drug Discovery

Fig. 7: BRI-50460 amyloid-42 oligomer-induced cPLA2α activation and tau phosphorylation in neurons derived from human iPSCs.

From: Development of potent, selective cPLA2 inhibitors for targeting neuroinflammation in Alzheimer’s disease and other neurodegenerative disorders

Fig. 7

A Representative images of the immunofluorescent staining of p-cPLA2α and p-Tau in human iPSC-derived neurons treated with 2.5 μM Aβ42 oligomers (Aβ42O) with or without 1 μM BRI-50460 for 72 hours. Quantification revealed that BRI-50460 (460) reduced Aβ42O-induced increases in p-cPLA2α (B) and p-tau (C) intensity. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Analyzed image numbers include CTRL (n = 13), Aβ42 O (n = 14), 460 (n = 14).

Back to article page