Table 5 Imaging core available resources & data

From: 15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN

Data:

Number of participants

Total assessment count

Number of participants with only 1 assessment

Number of participants with > 1 assessment

Mean assessments among participants with > 1 assessment

Distribution of assessment countb

MRI scans

643

1541

226

417

3.15

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MRI quantitative measurementsc

593

1409

201

392

3.08

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AV-1451 Tau PET scans and quantitative measurementsd

67

99

44

23

2.39

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MK-6240 Tau PET scans and quantitative measurements

31

37

26

5

2.20

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PiB PET scans

600

1318

234

366

2.96

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PiB PET quantitative measurements

549

1169

220

329

2.88

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FDG PET scans

577

1221

233

344

2.87

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FDG PET quantitative measurements

540

1117

223

317

2.82

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  1. aDIAN Obs Data Freeze 17 (DF17) was used to compute these numbers. There are 673 participants in DF17. The cutoff for DF17 was 6/30/2023.
  2. bThe leftmost bar represents participants with exactly 1 assessment, 2nd leftmost bar represents participants with exactly 2 assessments, etc.
  3. cQuantitative measurements from MRI scans include the volume and thickness of various brain regions.
  4. dQuantitative measurements from PET scans include the concentration of amyloid-beta plaques measured by PiB PET scans, tau tangles measured by Tau PET scans, and metabolic activity assessed by FDG PET scans within various brain regions.
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