Fig. 1: Genetic analysis of the TREM2 L15Q mutation.
From: A novel TREM2 L15Q in signal peptide domain and its influence on Aβ pathogenicity
A, B Sanger sequencing result confirming the c.44 T > A (p. Leu15Gln) mutation in a patient DNA sample. C Changes in amino acid bulkiness, polarity, and hydrophobicity resulting from the TREM2 mutation as predicted by ExPASy. D Predicted 3D protein structures of WT and L15Q mutation using BIOVIA Discovery Studio Visualizer.
