Fig. 3: Reduced Aβ phagocytosis in TREM2 L15Q mutant cells.
From: A novel TREM2 L15Q in signal peptide domain and its influence on Aβ pathogenicity
Aβ phagocytosis was confirmed after treating pHrodo labeled with Aβ42 in the transfected cells. A Representative confocal microscopy images showing Aβ uptake in cells. Magnification = 60×; Scale bar = 20 μm. B Quantification of phagocytosed Aβ fluorescence. Fluorescence signals were measured using Image J, and values were normalized to WT (n = 4). All Data represent mean ± SD. P-value was obtained using one-way ANOVA followed by Bonferroni’s post hoc test with significance set at P < 0.05. **P < 0.01.
