Fig. 4: Altered extracellular and endogenous Aβ species in TREM2 L15Q cells.
From: A novel TREM2 L15Q in signal peptide domain and its influence on Aβ pathogenicity
Aβ species was measured using ELISA kit. A–C Relative amounts of extracellular Aβ42, Aβ40, and Aβ42/40 ratio (n = 6). D Relative amount of endogenous Aβ42 (n = 6). All data were normalized to that in WT. Data represent mean ± SD. P-value was obtained using one-way ANOVA followed by Bonferroni’s post hoc test with significance set at P < 0.05. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
