We read with much interest, the published article ‘Plasma IL-6 levels during arm exercise in people with spinal cord injury’ by Umemoto et al.1 We wish to share our scientific views on the published topic. Interleukin-6, which is considered as one of the mediators of acute inflammation and acts as an anti-inflammatory response, was portrayed clearly to have an impact on arm exercises among subjects with spinal cord injury. Even though the study provided a new insight into the field of immunological component and its impact on exercises, we would like to suggest few more points to improve the research component in the respective field.

Regarding the subject selection criteria, the authors mentioned an important component of excellent health at the time of the study and no medications that would have affected the immune or endocrine system. We would surely like to query the term ‘excellent health’, as spinal cord injury patients had a certain amount of disability based on the level of the lesions.

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