Abstract
Study design:
Prospective cohort controlled trial design.
Objectives:
(i) To investigate mood benefits of adding group cognitive behaviour therapy (group-CBT) to standard spinal cord injury (SCI) inpatient rehabilitation (SR) that included access to antidepressant medication and individually delivered CBT on demand. (ii) To determine whether those with elevated depressive mood during inpatient rehabilitation significantly improve.
Setting:
SCI rehabilitation and community settings in New South Wales, Australia.
Methods:
Participants included 50 adults with SCI who completed SCI rehabilitation that included group-CBT compared with 38 participants who also completed SCI rehabilitation that did not contain group-CBT. Comprehensive assessment occurred after admission, within 2 weeks of discharge and 12 months post-injury. Multivariate repeated measures analyses were conducted to examine differences between groups and over time.
Results:
The addition of group-CBT to SR did not result in significant improvement in mood. However, participants with clinically elevated depressive mood assessed during inpatient rehabilitation experienced significant reductions in depressive mood when assessed in the community regardless of CBT dosage. Anxiety correlated with mood while no sociodemographic/injury factors correlated with mood at any time period except education level.
Conclusion:
There were no mood advantages over time of adding group-CBT to inpatient SCI rehabilitation that contains individually delivered CBT on demand and access to antidepressant medication. However, findings showed those with elevated depressive mood during inpatient rehabilitation significantly improved when assessed in the community; however, their levels of depressive mood remain high. Future research should investigate the efficacy of providing individual preferences for managing depression in people with SCI.
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References
Somers MF . Spinal Cord Injury: Functional Rehabilitation. Chicago: Prentice Hall. 2001.
Jensen MP, Kuehn CM, Amtmann D, Cardenas DD . Symptom burden in persons with spinal cord injury. Arch Phys Med Rehabil 2007; 88: 638–645.
Tate DG, Forchheimer MB, Karana-Zebari D, Chiodo AE, Thomas JYK . Depression and pain among inpatients with spinal cord injury and spinal cord disease: differences in symptoms and neurological function. Disabil Rehabil 2013; 35: 1204–1212.
Wijesuriya N, Tran Y, Middleton J, Craig A . The impact of fatigue on the health related quality of life in persons with spinal cord injury. Arch Phys Med Rehabil 2012; 93: 319–324.
Craig A, Rodrigues D, Tran Y, Guest R, Bartrop R, Middleton J . Developing an algorithm capable of discriminating depressed mood in people with spinal cord injury. Spinal Cord 2014; 52: 413–416.
Craig A, Nicholson Perry K, Guest R, Tran Y, Dezarnaulds A, Hales A et al. A prospective study of the occurrence of psychological disorders and co-morbidities following spinal cord injury. Arch Phys Med Rehabil 2015; 96: 1426–1434.
Fann JR, Bombardier CH, Richards JS, Tate DG, Wilson CS, Temkin N . Depression after spinal cord injury: comorbidities, mental health service use, and adequacy of treatment. Arch Phys Med Rehabil 2011; 92: 352–360.
Hancock K, Craig AR, Tennant C, Chang E . The influence of spinal cord injury on coping styles and self-perceptions: a controlled study. Aust N Z J Psychiatry 1993; 27: 450–456.
Hoffman JM, Bombardier CH, Graves DE, Kalpakjian CZ, Krause JS . A longitudinal study of depression from 1 to 5 years after spinal cord injury. Arch Phys Med Rehabil 2011; 92: 411–418.
Kennedy P, Rogers BA . Anxiety and depression after spinal cord injury: a longitudinal analysis. Arch Phys Med Rehabil 2000; 81: 932–937.
Williams R, Murray A . Prevalence of depression after spinal cord injury: a meta-analysis. Arch Phys Med Rehabil 2015; 96: 133–140.
Krueger H, Noonan VK, Williams D, Trenaman LM, Rivers CS . The influence of depression on physical complications in spinal cord injury: behavioral mechanisms and health-care implications. Spinal Cord 2013; 51: 260–266.
Soden R, Walsh J, Middleton J, Craven M, Rutkowski S, Yeo J . Causes of death after spinal cord injury. Spinal Cord 2000; 38: 604–610.
Tate D, Forchheimer M, Maynard F, Dijkers M . Predicting depression and psychological distress in persons with spinal cord injury based on indicators of handicap. Am J Phys Med Rehabil 1994; 73: 175–183.
Craig A, Tran Y, Middleton J . Psychological morbidity and spinal cord injury: a systematic review. Spinal Cord 2009; 47: 108–114.
Kishi Y, Robinson RG, Forrester AW . Prospective longitudinal study of depression following spinal cord injury. J Neuropsychiatry Clin Neurosci 1994; 6: 237–244.
Craig AR, Hancock KM, Dickson HG . A longitudinal investigation into anxiety and depression in the first 2 years following a spinal cord injury. Paraplegia 1994; 32: 675–679.
Andrews G, Henderson S, Hall W . Prevalence, comorbidity, disability and service utilisation: overview of the Australian National Mental Health Survey. Br J Psychiatry 2001; 178: 145–153.
Bonanno GA, Kennedy P, Galatzer-Levy IR, Lude P, Elfström ML . Trajectories of resilience, depression, and anxiety following spinal cord injury. Rehabil Psychol 2012; 57: 236–247.
Bombardier CH, Adams LM, Fann JR, Hoffman JM . Depression trajectories during the first year after spinal cord injury. Arch Phys Med Rehabil 2016; 97: 196–203.
Guest R, Craig A, Nicholson Perry K, Tran Y, Hales A, Ephraums C et al. Resilience following spinal cord injury: a prospective controlled study investigating the influence of the provision of group CBT during inpatient rehabilitation. Rehabil Psychol 2015; 60: 311–321.
Middleton J, Craig A. Psychological challenges in treating persons with spinal cord injury. In: Craig A, Tran Y (eds). Psychological Dynamics Associated with Spinal Cord Injury Rehabilitation: New Directions and Best Evidence, Chapter 1. Nova Science Publishers: New York, 2008, pp 3–54..
Fann JR, Bombardier CH, Richards JS, Wilson CS, Heinemann AW, Warren AM et al. Venlafaxine extended-release for depression following spinal cord injury: a randomized clinical trial. JAMA Psychiatry 2015; 72: 247–258.
Elliott TR, Kennedy P . Treatment of depression following spinal cord injury: an evidence-based review. Rehabil Psychol 2004; 49: 134–139.
Mehta S, Orenczuk S, Hansen KT, Aubut JA, Hitzig SL, Legassic M et al. An evidence-based review of the effectiveness of cognitive behavioral therapy for psychosocial issues post-spinal cord injury. Rehabil Psychol 2011; 56: 15–25.
Post M, Van Leeuwen C . Psychosocial issues in spinal cord injury: a review. Spinal Cord 2012; 50: 382–389.
Dorstyn D, Mathias J, Denson L . Efficacy of cognitive behavior therapy for the management of psychological outcomes following spinal cord injury: a meta-analysis. J Health Psychol 2011; 16: 374–391.
Dorstyn DS, Mathias JL, Denson LA . Psychological intervention during spinal rehabilitation: a preliminary study. Spinal Cord 2010; 48: 756–761.
Kennedy P, Duff J, Evans M, Beedie A . Coping effectiveness training reduces depression and anxiety following traumatic spinal cord injuries. Br J Clin Psychol 2003; 42: 41–52.
Duchnick JJ, Letsch EA, Curtiss G . Coping effectiveness training during acute rehabilitation of spinal cord injury/dysfunction: a randomized clinical trial. Rehabil Psychol 2009; 54: 123–132.
Craig A, Hancock K, Chang E, Dickson H . Immunizing against depression and anxiety after spinal cord injury. Arch Phys Med Rehabil 1998; 79: 375–377.
Craig A. In: Craig A, Tran Y (eds). Psychological Dynamics Associated with Spinal Cord Injury Rehabilitation: New Directions and Best Evidence, Chapter 5. Nova Science Publishers: New York, 2008, pp 131–154..
De Vivo MJ, Richards JS, Stover SL, Go BK . Spinal cord injury. Rehabilitation adds life to years. West J Med 1991; 154: 602–606.
Craig A, Moses P, Tran Y, McIsaac P, Kirkup L . The effectiveness of a “hands free” environmental control system for the profoundly disabled. Arch Phys Med Rehabil 2002; 83: 1455–1458.
Bonell CP, Hargreaves J, Cousens S, Ross D, Hayes R, Petticrew M et al. Alternatives to randomisation in the evaluation of public health interventions: design challenges and solutions. J Epidemiol Community Health 2011; 65: 582–587.
Lammertse D, Tuszynski M, Steeves J, Curt A, Fawcett J, Rask C et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord 2007; 45: 232–242.
Cripps RA, Harrison JE . Injury as a Chronic Health Issue in Australia. Australian Institute Health Welfare: Canberra. 2008.
Woolrich RA, Kennedy P, Tasiemski T . A preliminary psychometric evaluation of the Hospital Anxiety and Depression Scale (HADS) in 963 people living with a spinal cord injury. Psychol Health Med 2006; 11: 80–90.
Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD . The Fatigue Severity Scale; application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989; 46: 1121–1123.
Jensen MP, Turner JA, Romano JM, Fisher LD . Comparative reliability and validity of chronic pain intensity measures. Pain 1999; 83: 157–162.
Flor H, Behle DJ, Birbaumer N . Assessment of pain-related cognitions in chronic pain patients. Behav Res Ther 1993; 31: 63–73.
Walterfang M, Siu R, Velakoulis D . The NUCOG: validity and reliability of a brief cognitive screening tool in neuropsychiatric patients. Aust N Z J Psychiatry 2006; 40: 995–1002.
Hall KM, Cohen ME, Wright J, Call M, Werner P . Characteristics of the Functional Independence Measure in traumatic spinal cord injury. Arch Phys Med Rehabil 1999; 80: 1471–1476.
Kalpakjian CZ, Scelza WM, Forchheimer MB, Toussaint LL . Preliminary reliability and validity of a spinal cord injury Secondary Conditions Scale. J Spinal Cord Med 2007; 30: 131–139.
Faul FG . *Power Version 3.1.9.2. Kiel University: Germany. 2014.
Walker E, Nowacki AS . Understanding equivalence and non-inferiority testing. J Gen Intern Med 2011; 26: 192–196.
Jaccard J, Guilamo-Ramos V, Johansson M, Bouris A . Multiple regression analyses in clinical child and adolescent psychology. J Clin Child Adolesc Psychol 2006; 35: 456–479.
Cohen J . Statistical Power Analysis for the Behavioral Sciences. New Jersey: LEA. 1988.
Verwer JH, van Leeuwen CM, Bolier L, Post MW . Feasibility of an online well-being intervention for people with spinal cord injury: a pilot study. Spinal Cord 2016; 54: 473–477.
Munce SE, Straus SE, Fehlings MG, Voth J, Nugaeva N, Jang E et al. Impact of psychological characteristics in self-management in individuals with traumatic spinal cord injury. Spinal Cord 2016; 54: 29–33.
Fann JR, Crane DA, Graves DE, Kalpakjian CZ, Tate DG, Bombardier CH . Depression treatment preferences after acute traumatic spinal cord injury. Arch Phys Med Rehabil 2013; 94: 2389–2395.
Malhi GS, Bassett D, Boyce P, Bryant R, Fitzgerald PB et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Aust N Z J Psychiatry 2015; 49: 1087–1206.
van Leeuwen CM, Hoekstra T, van Koppenhagen CF, de Groot S, Post MW . Trajectories and predictors of the course of mental health after spinal cord injury. Arch Phys Med Rehabil 2012; 93: 2170–2176.
Craig A, Tran Y, Siddall P, Wijesuriya N, Lovas J, Bartrop R et al. Developing a model of associations between chronic pain, depressive mood, chronic fatigue and self-efficacy in people with spinal cord injury. J Pain 2013; 14: 911–920.
Piccinelli M, Wilkinson G . Gender differences in depression. Br J Psychiatry 2000; 177: 486–492.
Müller R, Cieza A, Geyh S . Rasch analysis of the Hospital Anxiety and Depression Scale in spinal cord injury. Rehabil Psychol 2012; 57: 214–223.
Acknowledgements
This work was financially supported by the Lifetime Care Support Authority, NSW, Australia (LTCSA Ref 08/209). We thank the following for assisting in the study: Ms Annalisa Dezarnaulds, Ms Alison Hales, Ms Catherine Ephraums, and Associate Professor Kathryn Nicholson Perry. We would also like to acknowledge the tremendous work that Professor Paul Kennedy has contributed to research designed to improve the life of people with SCI. He will be greatly missed.
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Craig, A., Guest, R., Tran, Y. et al. Depressive mood in adults with spinal cord injury as they transition from an inpatient to a community setting: secondary analyses from a clinical trial. Spinal Cord 55, 926–934 (2017). https://doi.org/10.1038/sc.2017.41
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DOI: https://doi.org/10.1038/sc.2017.41

