Figure 8: Effects of age and frailty on interstitial fibrosis and collagen content in the right and left atria.
From: Atrial structure, function and arrhythmogenesis in aged and frail mice
(A) Representative images demonstrating patterns of interstitial collagen deposition (red colour) in the right atrium (RA) and left atrium (LA) of young and aged mice. (B) Summary data quantifying right and left atrial fibrosis (measured from histological images as in panel A); data analyzed using Student’s t-test; n = 5 young and 5 aged hearts. (C) Linear regression analysis of interstitial fibrosis in the right and left atria as a function of FI score; n = 10 mice. (D) Effects of age on total collagen content in the right and left atria by hydroxyproline assay. Data analyzed using Student’s t-test; n = 14 young and 15 aged mice. (E) Linear regression analysis of total collagen content in the right and left atria as function of FI score, n = 29 mice.
