Figure 9: Ratios of expression of TIMPs to MMP2 in the right and left atria of young and aged mice.
From: Atrial structure, function and arrhythmogenesis in aged and frail mice
(A) Effects of age on the TIMP1/MMP2 mRNA expression ratio in the right (RA) and left (LA) atria. Data analyzed by Student’s t-test for the RA and Mann Whitney rank sum test for the LA; n = 8 young and 8 aged hearts. (B) Linear regression analysis illustrating correlations between the TIMP1/MMP2 expression ratio and FI score in the right and left atria; n = 16 hearts. (C) Effects of age on the TIMP2/MMP2 expression ratio in the right (RA) and left (LA) atria. Data analyzed by Student’s t-test for the RA and Mann Whitney rank sum test for the LA; n = 8 young and 8 aged hearts. (D) Linear regression analysis illustrating correlations between the TIMP2/MMP2 expression and FI score in the right and left atria; n = 16 hearts. (E) Effects of age on the TIMP3/MMP2 expression ratio in the right (RA) and left (LA) atria. Data analyzed by Student’s t-test; n = 8 young and 8 aged hearts. (F) Linear regression analysis illustrating correlations between the TIMP3/MMP2 expression ratio and FI score in the right and left atria; n = 16 hearts. (G) Effects of age on the TIMP4/MMP2 expression ratio in the right (RA) and left (LA) atria. Data analyzed by Mann Whitney rank sum test; n = 8 young and 8 aged hearts. (H) Linear regression analysis illustrating correlations between the TIMP4/MMP2 expression ratio and FI score in the right and left atria; n = 16 hearts.
