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Women with breast cancer and a BRCA1 or BRCA2 mutation face high risks of contralateral breast cancer, and many opt for bilateral mastectomy. We used a simulation approach to predict the benefit of risk-reducing mastectomy (RRM) on 20-year survival.
It has long been hypothesised that aspirin prevents cancer deaths by preventing metastasis. A recent study demonstrates this to be mediated through inhibition of Thromboxane A2 (TXA2) leading to reversal of suppression of T cell immunity. I appraise the context and future research implications of these findings.
Human papillomavirus (HPV) genotype infection causes cervical cancer, pharyngeal cancer, etc. The amount of circulating HPV DNA in the blood helps in detecting advanced/recurrent cancer earlier than with tumour marker elevation. Cancer immunotherapy is more effective for HPV infection-positive than for HPV infection-negative cancer.
