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Gut microbiome-virome dynamics and interactions

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The gut virome and microbiome form an interactive ecosystem that shapes immunity, metabolism and disease risk. Virome shifts can respond rapidly to diet or therapy and may precede bacterial changes. We welcome studies that interrogate microbiome-virome interactions with functional or mechanistic depth, including immune crosstalk with macrophages and other phagocytes, phage-bacteria ecology and AMR, diet- or therapy-responsive viromes, and multi-omics links to metabolites, inflammation and clinical outcomes. Descriptive surveys without a virome component or functional insight are out of scope.

In this Collection, we invite original research, comprehensive reviews, and perspectives focusing on, but not limited to, the following topics:

  • Virome-centred diet or drug interventions with linked bacterial and host outcomes.

  • In vivo phage-bacterium ecology, including lysogeny to lysis, host range and AMR mobilisation.

  • Immune and barrier interfaces covering macrophages, neutrophils, epithelial signalling and mucus.

  • Integrated multi-omics linking the virome to metagenome, transcriptome, proteome and metabolome.

  • Methods and standards for VLP enrichment, spike-ins, mock communities and platform benchmarking.

  • Translation and therapeutics, including diagnostics, faecal virome transfer, phage therapy and engineered phages

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Gut microbiome-virome dynamics and interactions

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