Collection 

Environmental ‘determinants’ in precision medicine

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Open
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Precision medicine has traditionally focused on the molecular and genetic basis of disease, aiming to tailor prevention and treatment strategies to individual biological profiles. However, it is now increasingly recognized that environmental exposures—including chemical agents, dietary factors, physical stressors, and microbial environments—profoundly influence disease onset, progression, and therapeutic response. The dynamic interplay between genome and environment is particularly relevant in complex, multifactorial diseases, where gene-environment and epigenome-environment interactions modulate risk and clinical heterogeneity.

This Collection of npj Genomic Medicine will focus on the integration of environmental determinants into precision medicine frameworks, with an emphasis on how exposures affect molecular pathways and influence health outcomes through genomic, epigenomic, transcriptomic, and other omic mechanisms. We welcome contributions that characterize environmental influences on gene regulation and function, define molecular biomarkers of exposure and response, or employ multi-omic and computational approaches to dissect individual variability in susceptibility and treatment efficacy.

Of particular interest are studies that explore the molecular consequences of defined environmental exposures, such as pollutants and xenobiotics, and their interaction with inherited or somatic genomic features. We are also interested in translational research that connects molecular signatures of environmental exposure with clinical phenotypes, therapeutic responses, or disease trajectories.

This Collection aims to advance the understanding of how modifiable environmental factors can be systematically incorporated into genomic medicine. By emphasizing mechanistic insights and clinically relevant applications, the collection seeks to support a more comprehensive and actionable model of precision health.

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Editors

  • Nicola Normanno, MD , 

    Nicola Normanno, MD

    Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori” IRCCS, Meldola (FC), Italy

  • Paola Ulivi, PhD  &

    Paola Ulivi, PhD

    Biosciences Laboratory, IRCCS Istituto Romagnolo per lo studio del Tumori “Dino Amadori” (IRST), Meldola (FC), Italy

  • Milena Urbini, PhD

    Milena Urbini, PhD

    Biosciences Laboratory, IRCCS Istituto Romagnolo per lo studio del Tumori “Dino Amadori” (IRST), Meldola (FC), Italy

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