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This review summarizes how catabolic rewiring lets tumors harvest fuels and why dietary interventions have limited impact on nutrient supply but meaningful endocrine and immune benefits that burden tumor metabolism and complement standard care.
Our review summarizes recent advances in understanding the diverse roles of nuclear lamins in mitosis and discusses how their dysregulation - observed in several diseases - could affect this essential process required for faithful genome inheritance.
A review of recent innovations driving low-input phosphoproteomics, focusing on miniaturized workflows, multiplexed labelling, automated enrichment, and advanced acquisition methods for scarce biological material.
This Review highlights how extremophile microbiomes and synthetic biology approaches could support Martian terraforming by driving biogeochemical cycles, regolith transformation, and future life-support ecosystems.
This review applies the allostasis framework to complex diseases, linking chronic stress and allostatic load to drug addiction, immune diseases, and cancer, and highlights multi-omics, iPSC, and organoid technologies as emerging tools to study them.
This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic potential in metabolism and neuroprotection.
This review explores the genomic diversity, ecology, and functional potential of the bacterial family Endozoicomonadaceae in marine symbioses, highlighting their mutualistic to parasitic spectrum and key gaps to be addressed in future research.
This review summarizes the current progress on linguistic neural decoding from a machine learning perspective, focusing on the extraction and generation of text and speech information from brain activity patterns.
A review summarizes the knowledge about the role of redox homeostasis in the functioning of skin melanocytes and about the possibilities of influencing this status by natural compounds, including vitamins, as well as polyphenols or phytocannabinoids.
This review article discusses the challenges of identifying cancer cells in single-cell data, summarizing current computational solutions as well as underexplored features of malignancy.
ADMSCs offer promise for Type 1 Diabetes therapy due to their immunomodulatory and regenerative properties. This review highlights current findings, clinical relevance, and challenges in translating ADMSC-based treatments into standard care.
This review summarizes how TLR2 and TLR4 mediate physiological and pathological inflammation in reproduction, highlighting their signaling pathways, regulatory mechanisms, and implications for fertility and therapeutic strategies.
Sperm navigate the human Fallopian tube by three distinct processes. While their behavioral mechanisms are known, their molecular basis is gradually being uncovered. These processes can improve in vitro fertilization outcomes in clinical settings.
A review summarizes how progranulin (PGRN) regulates lipid metabolism, dysregulation of which contributes to neurodegeneration. Hence, PGRN represents a promising therapeutic target for restoring lipid homeostasis and mitigating neurodegeneration.
A review summarizes the interplay of the lung microenvironment in metastatic osteosarcoma in human and canines, including immune and resident lung cells, and how this knowledge can inform treatment for both patient populations.
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility.
This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs.
This review surveys the core metabolic fluxes employed by sebaceous glands to achieve sebum synthesis and examines the idea that metabolic-driven processes are an important mechanistic component of holocrine secretion.
A review summarizes the current understanding of the complex molecular pathways mediating plant responses to multiple abiotic stresses, and discusses current and future challenges and unanswered questions.
