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Focus on Brain Tumors
This collection, curated by Ho-Keung Ng of the Chinese University of Hong Kong, focuses on the underlying pathogenetic and molecular processes that contribute to brain tumors. Papers include a review on grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System, a description of circulating tumor DNA profiling for childhood brain tumors, and a study on the plasticity of glioma stem cells in response to changes in the microenvironment.
Image: James Innes -
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Laboratory Investigation Focus on China
The editors of Laboratory Investigation are proud to present a Web Focus that showcases research by authors from institutions across China. We selected recent papers to highlight the significant contributions of Chinese scientists and to introduce the journal to an even wider audience. 《实验室研究》杂志：聚焦中国 《实验室研究》杂志编辑很荣幸地向读者呈现来自中国研究机构作者的网络热点研究。我们选取一系列近期发表的论文以彰显中国科学家所作的重要贡献，同时希望将本杂志推荐给更广泛的读者。
Image: Getty Images -
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Advances in Translational Pathology
Brightfield microscopy is the preferred method of pathologists for diagnosing solid tumors, utilizing common staining techniques such as hematoxylin and eosin staining and immunohistochemistry.
Image: Daniel R. Bauer -
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TRP ion channels in the pathobiology of disease
The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch”. In recognition of their work, the LI editors present an updated collection of papers that explore the mechanisms of transient receptor potential ion channels. Transient receptor potential (TRP) ion channels serve as cellular sensors that respond to a range of physical and chemical stimuli. Twenty-eight mammalian TRP ion channels have been reported, which belong to six subfamilies (TRPV, TRPM, TRPC, TRPA, TRPP, and TRPML). This collection of articles from Laboratory Investigation describes the roles of various TRP ion channels in inflammation, fibrosis and cancer.
Image: Koji ShibasakiOpen for submissions -
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Focus on the Eye
The editors of Laboratory Investigation and Modern Pathology present a variety of recent papers related to ocular pathology. These experimental and diagnostic studies cover congenital anomalies, corneal injury and repair, degenerative disease, and various malignancies.
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Focus on Europe: Advances in Translational Pathology
This Laboratory Investigation web focus highlights innovative models and techniques from European contributors. These papers feature advances in molecular genetics, metabolomics, diagnostic imaging, biomarker discovery, and animal models of human disease.
Image: Helge Taubert -
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The nucleoside diphosphate kinase superfamily: state of the art
Nucleoside diphosphate kinases (NDPK), encoded by NME (NM23) genes, control intracellular nucleotide homeostasis. In this collection, the authors discuss three major cellular processes that involve members of the multi-functional NME/NDPK family: cancer and metastasis dissemination, membrane remodeling and nucleotide channeling, and protein histidine phosphorylation.
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Focus on Renal Pathology
Kidney disease affects over 26 million Americans, resulting in a high demand for elucidating the pathways that lead to renal pathologies and identifying potential therapeutic targets. In this Web Focus presented by Laboratory Investigation, recent research in the field of renal pathology is highlighted.
Image: George F. Murphy
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