Research Highlights

Combining neuroimaging with molecular and cellular data reveals how microscale features shape large-scale brain networks.

Cas9-based ribonucleoproteins engineered via directed evolution and encapsulated in optimized lipid nanoparticles improve genome-editing efficacies in the livers and lungs of mice.

High-throughput screening led to the identification of artesunate as an antifibrotic agent that targets the glycoprotein myeloid differentiation factor 2 in the infarcted heart.

Organic nanoprobes facilitate the imaging of small deep-seated tumours in mice via the X-ray-mediated generation of long-lasting luminescence.

An autologous transplant of islets derived from chemically induced pluripotent stem cells allowed an individual with type 1 diabetes to forgo insulin.

An agonist of the neurokinin 2 receptor induced weight loss and increased energy expenditure in obese mice and monkeys with diabetes.

RNA-targeting CRISPR screens reveal hundreds of functional long non-coding RNAs that are crucial for cell survival and implicated in cancer progression.

Virus-like particles can be evolved to enhance the delivery of ribonucleoproteins and to increase particle production.

A large vision–language model trained to generate chest X-ray reports shows promise as an assistive tool for radiologists, particularly for typical cases in outpatient settings.

Proteins that tag surface receptors for degradation by triggering their endocytosis can be computationally designed so that they do not compete with native receptor ligands for binding.

DNA microbeads loaded with an agonist for Wnt and injected into retinal organoids allow for the spatiotemporal control of gradients of the morphogen to better direct organoid development and maturation.

A biomarker in retinal images identified by a deep-learning algorithm can predict biological age as well as mortality and morbidity.

A water-soluble dye that absorbs blue light strongly makes it easier to turn mice transparent.