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A closed-loop and wireless 128-channel neuromodulation device enables electrical stimulation as well as artefact-free long-term recording of local field potentials in the brain of an untethered non-human primate.
An interpretable deep-learning algorithm trained on a small dataset of computed-tomography scans of the head detects acute ICH and classifies the pathology subtypes, with a performance comparable to expert radiologists.
A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.
A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.
Coating continuous glucose-monitoring sensors with zwitterionic polymer reduces early inflammatory responses and signal noise after sensor implantation in live animals, and improves the performance of the sensors without the need for additional recalibration.
Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease.
Minimally invasive intravascular electrodes chronically implanted via the superior sagittal sinus can stimulate the motor cortex of sheep, and elicit muscular activity.
A tissue-engineered scale model of the human ventricle made of nanofibrous scaffolds and human-stem-cell-derived cardiomyocytes enables the modelling of arrhythmia.
Co-cultures of muscle cells and optogenetic motor neurons derived from patient-specific human stem cells make a physiologically relevant model of amyotrophic lateral sclerosis.
A machine-learning algorithm reliably predicts Cas9-edited genotypes arising from the repair of DNA double-strand breaks in mouse cells and human cells.
Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.
CRISPR–Cas9-mediated genome editing can be activated locally in vivo via an applied magnetic field, after complexation of magnetic nanoparticles with recombinant baculoviral vectors packaging the CRISPR–Cas9 machinery.
The coupling of blood platelets bearing anti-programmed cell death protein 1 antibodies to haematopoietic stem cells enables delivery of checkpoint-blockade therapy to bone marrow to promote T-cell-mediated control of leukaemia in mice.
Widespread editing of the mutated DMD gene by CRISPR–Cas9, systemically delivered via an adeno-associated virus, restores dystrophin expression in a canine model of Duchenne muscular dystrophy.
Transplanting allogeneic pancreatic islets intraperitoneally by first encapsulating the islets within an alginate-based formulation results in reduced fibrosis and capsule clumping, and thus in improved islet survival.
DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.
This Perspective discusses the importance of proper study design in preclinical studies in nanomedicine and cell therapy to improve reproducibility and the likelihood of clinical translation.
The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.
