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Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
In this Perspective, the functions of the recently identified post-translational-modification protein l-lactylation in the regulation of cellular metabolism and signalling are discussed, highlighting the potential of l-lactylation as a therapeutic target.
In this Perspective, Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets.
