News & Views

A new peptide sequencing approach converts amino acids into DNA sequences, which are easily read.

A tissue-engineered esophageal graft supports luminal patency in growing minipigs with emerging structural integration.

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.

Engineered blood vessels harness artificial intelligence (AI) and magnetoelasticity to continuously monitor blood flow and stenosis in real time.

RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate.

In a major step toward clinical translation, transplanting stem cells into the injured spinal cords of rhesus monkeys improves hand function.

Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model.

Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.

A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.

An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.

Two seminal studies report a bioengineering approach to modeling CAR-T cell therapy of solid human tumors.

Transient expression of a transcription activator-like effector (TALE)-based epigenetic editor demonstrates durable therapeutic silencing in non-human primates.

Spermatid-like haploid stem cells produce genome-edited farm animals in one generation.

A method to produce embryonic stem cells for a range of bird species opens up opportunities in agriculture, developmental biology and species conservation.

A strategy for treating chronic multidrug-resistant staphylococcal infections kills bacteria by encasing them in a calcium shell.

A clinical trial attempts to standardize fetal cell transplantation and highlights challenges to be addressed in upcoming studies that use stem cell-derived neuron progenitors.

Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.

The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing.

A self-supervised approach to learning from 24 million spectra generates a foundation model for detecting and characterizing small molecules by tandem mass spectrometry.

Hyperspectral reporters allow bacteria on the ground to be imaged by high-flying drones, expanding environmental monitoring to large outdoor areas.