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Understanding how proteins function in isolation and in their native context requires a merging of molecular-level techniques that explore the interplay of protein structure and dynamics.
Building on a century of enzymology research and new genome-wide insights into enzyme families, increased interdisciplinary communication and a broad vision will advance our understanding of biological catalysts and enhance our ability to manipulate them.
Identifying and increasing access to the highest quality chemical probes will ensure their prominent position in the biological and drug discovery toolboxes.
With a new administration and pending increases in scientific funding, chemical biologists in the United States have an unprecedented opportunity to influence the national scientific agenda.
Providers and users of chemical libraries must adopt quality and reporting standards to advance the impact of small-molecule high-throughput screening.
