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Analysis of 653 regions across 31 countries revealed that socioeconomic conditions and regional variation in the pace of renewable energy adoption were linked to disparities in air pollution-related mortality.
The breast cancer screening trial found that using automated artificial intelligence to triage and support decisions in mammography and digital breast tomosynthesis was not noninferior to double reading.
In clinical validation of a liquid biopsy assay, the approach enabled fast and accurate molecular diagnosis of EBV+ Burkitt’s lymphoma in more than 200 children and young adults in Tanzania and Uganda.
Data from the 100 Million Brazilian cohort reveal that tuberculosis diagnosis (even with treatment) increases risk of death due to oncological, cardiovascular, endocrine and respiratory causes.
An exposome-wide association study of 619 exposures and 305 quantitative phenotypes shows that blood lipids, persistent pollutants and vitamin E are key contributors to phenotypic health traits.
In a double-blind, cluster-randomized, placebo-controlled trial in Niger that examined azithromycin mass drug distribution in different age groups of children, there was evidence of selection of macrolide resistance determinants in the gut in children 1 to 59 months old, but resistance to other classes of antibiotics were not observed in the gut or nasopharynx.
A ‘universal vaccine’ administered intranasally provided mice broad protection against respiratory bacteria and viruses, paving the way for human studies.
Artificial intelligence models are evolving from chats to hypotheses. Now their ideas are being validated in organoids and animals — and even in early-stage clinical trials.
In cohort 4 of the ILUSTRO trial, combination of anti-CLDN18.2 zolbetuximab plus mFOLFOX6 and nivolumab in patients with CLDN18.2-positive, HER2-negative metastatic gastric or gastroesophageal junction adenocarcinoma led to encouraging clinical efficacy, supporting the testing of this combination in a phase 3 trial.
The field of genetic therapies needs robust investments, transparency and reliable regulatory frameworks to overcome recent challenges and continue to translate new technologies into patients’ benefit.
Using global cancer incidence data from 185 countries, this study shows that four in ten cancers worldwide are attributable to modifiable risk factors. The findings highlight substantial opportunities for prevention through targeted, population-level interventions adapted to regional and sex-specific risk profiles.
In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.
A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.
The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.
Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.
This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.
Using individual-level data from the Swedish Prescribed Drug Register and fecal metagenomes of 14,979 individuals in Sweden, the authors examined the association between oral antibiotic use over 8 years and gut microbiome and found evidence that antibiotics can have long-lasting impacts on the gut microbiome.
Data show that nutrient supplementation can modify epigenetic clock-based measurements of biological age, a major advance for the supplement field; however, whether such interventions can increase healthspan remains an open question.
