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Perspectives in 2025

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  • Cities are often at the forefront of creative thinking on policy opportunities; this Perspective outlines an agenda for urban health research that promotes a virtuous cycle by which population health and environmental sustainability support and reinforce each other.

    • Ana V. Diez Roux
    • Usama Bilal
    Perspective
  • Research does not always ‘speak for itself’; high-fidelity uptake of science into policy requires active engagement between researchers and policymakers. This Perspective offers tangible recommendations to help bridge the research-to-policy gap.

    • J. Jaime Miranda
    • David Beran
    • Kent Buse
    Perspective
  • The authors present a 5-year action plan that prioritizes high-impact, practical interventions in brain health across six key areas—to safeguard the continent’s health and economic stability alongside projected demographic shifts.

    • Mie Rizig
    • Connor McLaughlin
    • George Vradenburg
    Perspective
  • Insights into TB heterogeneity are informing strategies for patient stratification and treatment shortening; this Perspective discusses the formidable challenge of treating this complex disease with strategies that can be implemented across global settings, for effective disease control.

    • Véronique A. Dartois
    • Valerie Mizrahi
    • Clifton E. Barry III
    Perspective
  • This Perspective explains how past migrations and environmental exposures have influenced genomic diversity, and how understanding and contextualizing this diversity is crucial to advancing precision medicine and equitable healthcare.

    • María J. Palma-Martínez
    • Yuridia S. Posadas-García
    • Mashaal Sohail
    Perspective
  • Parkinson’s diseases and other synucleinopathies are on the verge of a major paradigm shift toward being defined and staged by their biology, rather than symptoms; this Perspective offers context on progress, needs and opportunities toward this goal.

    • Claudio Soto
    • Brit Mollenhauer
    • Kathleen Poston
    Perspective

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